The miR-17/92 cluster is also known as ‘oncomiR-1’. The miR-17/92 cluster is very often dysregylated in hematopoietic and solid cancers. Are there any protein-coding genes that are important forThe miR-17/92 cluster is often dysregylated in cardiovas-cular, immune and neurodegenerative diseases. The miR-17/92 cluster has been implicated in

Det har rapporterats att flera miRNA i miRNA 17-92-klustret uttrycks rikligt i (A), hierarkisk clustering visade de differentiellt uttryckta miRNA bland human 

The miRNA cluster miR-17-92 is known to act as an oncogene in various cancers. Members of this cluster were also found to be involved in some other pathological process, such as steatosis, which is a pivotal event in the initiation and progression of nonalcoholic fatty liver disease (NAFLD). tant miRNA of the miR-17-92 cluster in c-Myc-induced lymphomagenesis, both groups studied the mRNA tar-gets of miR-19. Mu et al. (2009) analyzed changes in gene expression in a lymphoma cell line derived from a mouse homozygous for the inducible deletion of the miR-17-92 cluster and heterozygous for Em-Myc.

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First evidence that the miR-17~92 cluster may be involved in tumori-genesis was provided by studies showing that the C13orf25 locus, which encodes the primary transcript of the miR-17~92 cluster, is frequently overexpressed in B-cell lymphoma cell lines.2 Subsequent Background: The miRNA cluster miR-17-92 is known to act as an oncogene in various cancers. Members of this cluster were also found to be involved in some other pathological process, such as steatosis, which is a pivotal event in the initiation and progression of nonalcoholic fatty liver disease (NAFLD). This study aimed to explore Interestingly, deletion or overexpression of miR-17- 92 cluster in keratinocytes, or deletion of miR-17-92 in T cells did not significantly affect IMQ-induced psoriasis- like dermatitis develop-ment in the mutant mice compared with wild-type littermates. Thus, miRNA miR-17- 92 cluster Many RNAs are processed into biologically active transcripts, the aberrant expression of which can contribute to disease phenotypes. For example, the primary microRNA-17-92 (pri-miR-17-92) cluster contains six microRNAs (miRNAs) that collectively act in several disease settings. Herein, we used sequence-based design of structure-specific ligands to target a common structure in the Dicer Members of the miRNA gene cluster can coordinate the regulation of certain processes or play a similar role in the same biological process, ensuring biological activity occurs in a normal and orderly fashion.

2018-04-18 Therefore, miRNA 17–92 cluster may be involved in Y79 cell invasive property. Earlier, reports have shown that miR 17–92 cluster inhibits PTEN expression in human hepatocellular cancer and mouse lymphoproliferative disorders, and resulted in increased tumor … Overexpression of the miR-17-92 cluster in MLL-rearranged leukemias.

The miRNA-17 ∼ 92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. Leukemia 26, 1064–1072 (2012). https:

Different studies have shown that 18.7 to 37% of all human miRNA genes are clustered. miR-17–92 polycistronic cluster overexpression is associated with human hematolymphoid and solid malignancies including breast … The AUC for combined detection by using the 6 miRNAs of miR-17–92 cluster was higher than that for each miRNA alone (Fig.

Olive et al. (2009) approached the dissection of the miR-17-92 cluster from the opposite side, by overexpression of different miRNA components in the Eμ-Myc-induced B-cell lymphomas. They found that overexpression of the entire cluster, the cluster without miR-92, but not when miR-19a and miR-19b were lost, enhanced oncogenesis.

This study aimed to explore Interestingly, deletion or overexpression of miR-17- 92 cluster in keratinocytes, or deletion of miR-17-92 in T cells did not significantly affect IMQ-induced psoriasis- like dermatitis develop-ment in the mutant mice compared with wild-type littermates. Thus, miRNA miR-17- 92 cluster Many RNAs are processed into biologically active transcripts, the aberrant expression of which can contribute to disease phenotypes. For example, the primary microRNA-17-92 (pri-miR-17-92) cluster contains six microRNAs (miRNAs) that collectively act in several disease settings.

For example, the use of miR-17 antagonists represents a novel therapeutic approach to the treatment of chronic lymphocytic leukemia . Usually, miRNA clusters consist of two or three miRNAs, but larger clusters also exist, for example, the miR-17-92 cluster is found on human chromosome 13 and is composed of six miRNAs. miRNA Usually, miRNA clusters consist of two or three miRNAs, but larger clusters also exist, for example, the miR-17-92 cluster is found on human chromosome 13 and is composed of six miRNAs.
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For example, the use of miR-17 antagonists represents a novel therapeutic approach to the treatment of chronic lymphocytic leukemia . Usually, miRNA clusters consist of two or three miRNAs, but larger clusters also exist, for example, the miR-17-92 cluster is found on human chromosome 13 and is composed of six miRNAs. miRNA Usually, miRNA clusters consist of two or three miRNAs, but larger clusters also exist, for example, the miR-17-92 cluster is found on human chromosome 13 and is composed of six miRNAs.

https: MicroRNA-17-92 cluster mediates the proliferation and survival of neural progenitor cells after stroke. J Biol Chem.
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miR-17∼92 miRNA Cluster Is Up-Regulated in Mouse Models of PKD. To identify miRNAs that are differentially expressed between cystic kidneys and normal kidneys, we performed miRNA microarrays using RNA from kidneys of control and kidney-specific-cadherin (Ksp)/cre;Kif3a F/F (Kif3a-KO) mice, an animal model of PKD.

52). The transcription of mir-17-92 is directly activated by both c-MYC and N-myc oncoproteins. Microarray profiling of cultured oligodendrocytes identified the miR-17-92 miRNA cluster as highly enriched in oligodendrocytes. We specifically deleted the miR-17-92 cluster in oligodendrocytes using 2,3 -cyclic nucleotide 3 phosphodiesterase (Cnp)-Cre mice.